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Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV
Author(s) -
Santos Lucas M.,
Lobato Rubens C.,
Barral Maria Fernanda M.,
Gonçalves Carla V.,
Hora Vanusa P.,
Martinez Ana Maria B.
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12175
Subject(s) - medicine , confidence interval , transmission (telecommunications) , obstetrics , prenatal care , human immunodeficiency virus (hiv) , pregnancy , multivariate analysis , risk factor , gynecology , demography , population , immunology , environmental health , electrical engineering , biology , engineering , genetics , sociology
Objective To determine the prevalence of human pegivirus ( HP gV) and factors associated with vertical transmission among pregnant women infected with HIV . Method A retrospective cross‐sectional study was conducted among pregnant women treated at an HIV reference service in Rio Grande, Brazil, between January 1, 2010, and January 1, 2015. The polymerase chain reaction was used to diagnose HP gV infection among the women and their neonates. Clinical, obstetric, and neonatal data were obtained from medical records. Results Infection with HP gV was detected among 16 (25%) of 63 women and 5 (8%) of 63 newborns, corresponding to a vertical transmission rate of 31%. Multivariate analysis demonstrated that the absence of prenatal care was the only risk factor for vertical transmission of HP gV (prevalence ratio 19.61, 95% confidence interval 1.29–297.48; P= 0.032). Conclusion Prenatal care could protect against vertical transmission of HP gV among women infected with HIV ; however, studies among HIV ‐negative individuals are still required to verify this correlation.