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Pre‐implantation genetic screening among women experiencing recurrent failure of in vitro fertilization
Author(s) -
Hatirnaz Safak,
Ozer Alev,
Hatirnaz Ebru,
Atasever Melahat,
Başaranoglu Serdar,
KanatPektas Mine,
Api Murat
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12135
Subject(s) - medicine , in vitro fertilisation , implantation failure , human fertilization , andrology , gynecology , obstetrics , genetics , pregnancy , infertility , anatomy , biology
Objective To determine the efficiency of pre‐implantation genetic screening ( PGS ) among women scheduled to undergo intracytoplasmic sperm injection who had experienced recurrent in vitro fertilization ( IVF ) failure. Methods The present retrospective cohort study reviewed the medical records of consecutive women who had experienced recurrent IVF failure and had presented at a private IVF facility in Trabzon Province, Turkey, to undergo intracytoplasmic sperm injection between May 1, 2012, and December 31, 2014. Patient data and perinatal outcomes were compared between patients who underwent PGS and those who did not. Results There were 88 patients included in the study; 43 patients had undergone PGS and 45 had declined to do so. No differences were detected in the clinical pregnancy rate ( P =0.846), spontaneous abortion rate ( P =0.416), number of perinatal deaths ( P =0.162), or the number of live deliveries ( P =0.188) between the groups of patients. The pregnancies included in the study resulted in 25 neonates being delivered; 24 had normal karyotypes, and one neonate from the control group had a karyotype of 46, XX , 9ph. Among the 19 embryos that were not transferred, the most frequently encountered chromosomal anomalies were diploidy, monosomy X, and 2N/N/4N mosaicism, detected in 7 (37%), 2 (11%), and 2 (11%) embryos, respectively. Conclusion PGS had no effect on perinatal outcomes among women experiencing recurrent IVF failure.