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Age‐related changes in pre‐ and post‐conization HPV genotype distribution among women with high‐grade cervical intraepithelial neoplasia
Author(s) -
Giannella Luca,
Fodero Cristina,
Boselli Fausto,
Rubino Teresa,
Mfuta Kabala,
Prandi Sonia
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12106
Subject(s) - medicine , cervical intraepithelial neoplasia , cervical conization , incidence (geometry) , gynecology , genotype , retrospective cohort study , genotyping , cervical cancer , risk factor , hpv infection , obstetrics , surgery , cancer , biochemistry , physics , optics , gene , chemistry
Abstract Objective To assess the effect of age on pre‐ and post‐conization HPV genotype distribution. Methods The present retrospective observational study included consecutive women with high‐grade cervical intraepithelial neoplasia who underwent conization at the Cervical Cancer Screening Centre of Reggio Emilia, Italy, and University Hospital of Modena, Italy, between February 1, 2012, and October 31, 2014. Pre‐conization and 6‐month post‐conization HPV genotyping results were compared between four age groups (<30, 30–39, 40–49, and ≥50 years) and age‐related changes in the HPV genotypes present were evaluated. Results There were 162 patients included. The lowest occurrence of pre‐conization high‐risk and probable high‐risk HPV genotypes was observed among patients aged at least 50 years when compared with younger patients ( P= 0.017). Conversely, women aged at least 50 years exhibited the highest level of post‐conization high‐risk and probable high‐risk HPV genotypes ( P= 0.043). Additionally, an increasing incidence of recording identical pre‐ and post‐conization HPV genotypes was associated with increasing age ( P= 0.024), as was increasing post‐treatment recurrence of cervical intraepithelial neoplasia grade 2+ ( P= 0.030). Conclusion The presence of high‐risk and probable high‐risk HPV genotypes was lowest among older patients before conization and was highest among these patients post‐conization; post‐treatment HPV clearance decreased with age and increasing age could be a risk factor for post‐conization recurrence.