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Cross‐sectional study of fetal long‐bone length in an Iranian population at 17–25 weeks of gestation
Author(s) -
Kasraeian Maryam,
Shahraki Hadi Raeisi,
Asadi Nasrin,
Vafaei Homeira,
Sameni Safoura
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12099
Subject(s) - ulna , tibia , humerus , femur , medicine , fibula , long bone , population , gestational age , gestation , fetus , orthodontics , obstetrics , anatomy , pregnancy , surgery , biology , genetics , environmental health
Objective To construct improved reference charts for fetal long bones in an Iranian setting and to compare them with previous studies. Methods The present prospective cross‐sectional study included singleton fetuses assessed by ultrasonography at 17–25 weeks of gestation at the Comprehensive Medical Genetics Center, Shahid Soltani, Shiraz, Iran between May 1, 2012, and February 28, 2014. Exclusion criteria included conditions that could affect fetal growth. Fetal long bones (femur, humerus, tibia, fibula, ulna, and radius) were measured with ultrasonography and biometric charts were produced. Regression models were fitted to estimate bone lengths. The models produced were compared with those from previous studies in other populations. Results There were 660 singleton fetuses included and 660 femur, 633 humerus, 512 tibia, 498 fibula, 505 ulna, and 498 radius biometric measurements were recorded. The models generated to predict the length of the tibia, fibula, ulna, and radius from the length of the femur and humerus demonstrated a high goodness of fit when the predicted lengths were plotted against the actual lengths. Comparisons of mean lengths with previous studies suggested that long‐bone length was affected by maternal ethnicity. Conclusion The equations generated could be used to predict long‐bone length in an Iranian population and ethnicity should be considered when using fetal long‐bone length as a prenatal diagnostic tool.