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Correlation between rapid HIV testing and fourth‐generation ELISA results for HIV detection among pregnant patients in the delivery room
Author(s) -
Almaguer Alejandro G.,
MendozaFlores Lidia,
SánchezLópez Luis A.,
PalauDávila Laura A.,
PadillaOrozco Magaly,
CamachoOrtiz Adrián
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12094
Subject(s) - medicine , cutoff , human immunodeficiency virus (hiv) , immunoassay , polymerase chain reaction , correlation , gold standard (test) , prospective cohort study , immunology , obstetrics , antibody , biology , biochemistry , physics , geometry , mathematics , quantum mechanics , gene
Objective To analyze the usefulness of rapid HIV testing in pregnant patients in the delivery room. Methods This prospective study compared a rapid test and a fourth‐generation enzyme‐linked immunoassay ( ELISA ) for HIV screening among pregnant patients admitted in labor with an unknown HIV status at a university hospital in Mexico between July 2015 and February 2016. Pearson correlation analysis was performed, and the diagnostic accuracy of the two tests was assessed with HIV RNA polymerase chain reaction ( PCR ) as the reference method. Results Overall, 534 patients were included. With a signal‐to‐cutoff (S/ CO ) value of 1.0 or more as a diagnostic criterion, 6 (1.1%) patients had a positive ELISA result. Three had a negative rapid test and three had a positive test ( r= 0.705). With an S/ CO value of 2.0 or more as cutoff, 4 (0.7%) patients had a positive ELISA result. Three had a positive rapid test and one had a negative test ( r= 0.865). Only three of six patients with an S/ CO of 1.0 or more were confirmed to have HIV by RNA PCR . Conclusion The rapid test showed a strong correlation with the fourth‐generation ELISA . Therefore, rapid testing is a useful tool in the delivery room for patients with unknown HIV status.