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Clinical outcomes for couples containing a reciprocal chromosome translocation carrier without preimplantation genetic diagnosis
Author(s) -
Yin Biao,
Zhu Yuanchang,
Wu Tonghua,
Shen Shuqiu,
Zeng Yong,
Liang Desheng
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12062
Subject(s) - intracytoplasmic sperm injection , preimplantation genetic diagnosis , in vitro fertilisation , assisted reproductive technology , chromosomal translocation , randomized controlled trial , gynecology , medicine , pregnancy , obstetrics , pregnancy rate , andrology , abortion , robertsonian translocation , karyotype , chromosome , biology , infertility , genetics , gene
Objective To evaluate the pregnancy outcomes of couples containing a carrier of a reciprocal chromosome translocation ( RCT ) after assisted reproductive technology without preimplantation genetic diagnosis. Methods A retrospective study was performed using data for couples with an RCT carrier and control couples with a normal karyotype (1:4 ratio) who underwent assisted reproductive technology cycles at a Chinese fertility center in 2010–2011. The embryos were fertilized via in vitro fertilization ( IVF ) or intracytoplasmic sperm injection ( ICSI ). Only the first pick‐up cycles were used for analysis. Clinical variables were compared. Results Compared with the control group (n=164), the RCT group (n=41) had a marginally lower clinical pregnancy rate (46.3% [19/41] vs 54.3% [89/164]), implantation rate (21.7% [23/106] vs 26.9% [118/438]), multiple‐gestation pregnancy rate (21.1% [4/19] vs 32.6% [29/89]), and delivery rate (36.6% [15/41] vs 47.6% [78/164]), whereas the spontaneous abortion rate was slightly higher (21.1% [4/19] vs 12.4% [11/89]). However, none of these differences were significant. Conclusion The clinical outcomes for RCT carriers were acceptable after IVF / ICSI without performing preimplantation genetic diagnosis, indicating that this approach might comprise a feasible alternative fertility treatment for RCT carriers.