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Predictive value of serum HE 4 and CA 125 concentrations for lymphatic metastasis of endometrial cancer
Author(s) -
Wang Yingmei,
Han Cha,
Teng Fei,
Bai Zhaoyi,
Tian Wenyan,
Xue Fengxia
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12010
Subject(s) - medicine , endometrial cancer , lymphadenectomy , metastasis , lymph node , oncology , lymph node metastasis , urology , carcinoma , stage (stratigraphy) , cancer , gastroenterology , paleontology , biology
Objective To evaluate the predictive value of serum HE 4 and CA 125 concentrations in the preoperative prediction of risk of lymph node metastasis in endometrial cancer. Methods A retrospective study was undertaken of data for patients with endometrial carcinoma treated surgically at a university hospital in China between August 2011 and December 2015. The preoperative serum levels of HE 4 and CA 125 were measured and analyzed by clinicopathologic characteristics. Results Overall, 258 patients were included. The HE 4 and CA 125 concentrations were significantly elevated in patients with large lesions (≥2 cm), deep myometrial invasion (≥50%), an advanced disease stage, or lymph node metastasis ( P <0.05 for all). HE 4 concentrations also rose with age and histologic grade ( P <0.01 for both). For lymph node metastasis, HE 4 had higher sensitivity and negative predictive value than did CA 125. The diagnostic performance of HE 4 and CA 125 in combination was superior to that of either marker alone. Conclusion The combined evaluation of serum HE 4 and CA 125 could provide gynecologic oncologists with improved information to guide the decision of whether to perform lymphadenectomy.