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Benzothiazole‐Phenothiazine Conjugate Based Molecular Probe for the Differential Detection of Glycated Albumin
Author(s) -
Kumar Ashish,
Datta Lakshmi Priya,
Samanta Sourav,
Arora Harshit,
Govindaraju Thimmaiah
Publication year - 2021
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.202000098
Subject(s) - chemistry , benzothiazole , bovine serum albumin , glycation , conjugate , amadori rearrangement , fluorescence , serum albumin , thioflavin , albumin , biochemistry , alzheimer's disease , medicine , disease , mathematical analysis , physics , receptor , mathematics , quantum mechanics
Glycation of albumin proteins is considered the pathophysiological hallmark of several chronic fatal disorders, including diabetes mellitus (DM) and Alzheimer's disease (AD). The optical detection of glycated albumin is a simple and cost‐effective tool with diagnostic implications for DM and AD. Herein, we developed a cyano derivative of the benzothiazole‐phenothiazine conjugate (T CN P) ‐based far‐red fluorescence probe for the differential detection of glycated bovine serum albumin (BSA G ) over native BSA and oxidized BSA (BSA O ). The selective fluorescence enhancement of T CN P in the presence of native BSA and BSA O and significant quenching in the presence of BSA G account for the distinct interaction between the probe and different structural variants of BSA. The high photostability and differential response towards native BSA and BSA G infer that T CN P is a potential molecular tool to assess the glycation induced structural changes of albumins.