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Thionation of the 2‐λ 5 ‐Phosphaquinolin‐2‐one Scaffold with Lawesson's Reagent
Author(s) -
Bard Jeremy P.,
McNeill J. Nolan,
Warren Gabrielle I.,
Zakharov Lev N.,
Johnson Darren W.,
Haley Michael M.
Publication year - 2021
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.202000085
Subject(s) - chemistry , reagent , thio , derivative (finance) , solid state , combinatorial chemistry , transformation (genetics) , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , financial economics , economics , gene
Lawesson's reagent is one of the most common thionating reagents that has found use for several decades on a variety of carbonyl systems. Herein, we report the transformation of the 2‐λ 5 ‐phosphaquinolin‐2‐one structure to its respective 2‐λ 5 ‐phosphaquinolin‐2‐thione derivative. Solution‐state characterization of both P−OPh and P−Ph thio analogues, as well as solid‐state structures for the latter system, are reported.