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Cover Picture: (Isr. J. Chem. 11‐12/2019)
Publication year - 2019
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201981101
Subject(s) - chemistry , cover (algebra) , nanodisc , electron paramagnetic resonance , nuclear magnetic resonance spectroscopy , kcsa potassium channel , nuclear magnetic resonance , nanotechnology , membrane , lipid bilayer , ion channel , biochemistry , physics , stereochemistry , mechanical engineering , engineering , receptor , materials science
The cover demonstrates the versatility of employing magnetic resonance for the investigation of biological systems. The left panel shows the extraction of a membrane protein from the cell wall, followed by solubilization in an appropriate membrane‐mimicking environment, here a lipoprotein nanodisc, thus making structural investigation possible. The middle panel shows how this approach applied to bacterial potassium channel KcsA allowed the application of NMR and EPR to follow the open‐to‐closed transition in the channel cytoplasmic domain under various conditions. The right panel describes a timeline of progress in the application of magnetic resonance to addressing biological problems, highlighting milestones in spectroscopy and imaging realizations of magnetic resonance ranging from first detection of MR signals to NMR inside cells, as well as Nobel‐prize recognition of these achievements.