Premium
An Update on Distal C( sp 3 )−H Functionalization Involving 1,5‐HAT Emerging from Nitrogen Radicals
Author(s) -
Goswami Nupur,
Maiti Debabrata
Publication year - 2020
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201900172
Subject(s) - chemistry , surface modification , radical , regioselectivity , nitrogen atom , hydrogen atom , nitrogen , combinatorial chemistry , selectivity , hydrogen bond , stereochemistry , medicinal chemistry , organic chemistry , catalysis , molecule , group (periodic table)
Methods to selectively functionalize any one sp 3 C−H bond among all others, has been well documented in literature. Radical reactions, which are essentially mild reaction conditions has provided a significant improvement over the standard functionalization pathways. Although radical recombinations are fast and feasible, the selectivity is always guided by the electronic biasness in the system. 1,n‐Hydrogen atom transfer (HAT) reactions are extremely useful in determining regioselectivity, the involvement of a 1,5‐HAT protocol made the reaction pathway energetically much more favourable to functionalize the desired remote C( sp 3 )−H bond. In this review we are going to give a brief overview of the methods involved in the functionalization of distal aliphatic C−H bond by 1,5‐HAT transformation pathway.