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BippyPhos: A Highly Versatile Ligand for Pd‐Catalyzed C−N, C−O and C−C Couplings
Author(s) -
Singer Robert A.
Publication year - 2020
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201900170
Subject(s) - chemistry , amination , ligand (biochemistry) , catalysis , halide , combinatorial chemistry , aryl , palladium , coupling (piping) , stereochemistry , organic chemistry , mechanical engineering , alkyl , biochemistry , receptor , engineering
Numerous ligands have been designed for the Buchwald‐Hartwig Amination (BHA). Among the ligands developed is BippyPhos. This ligand was originally designed to enable a coupling of primary amines with aryl halides. Further studies showed that the ligand has fairly broad utility for Pd‐catalyzed C−N, C−O and C−C couplings. This review describes the various Pd‐catalyzed applications involving BippyPhos as a supporting ligand. While BippyPhos may not often be the most optimal ligand for various Pd‐catalyzed couplings, it typically will provide adequate results as a starting point prior to screening for optimization.