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Photoredox‐Mediated Net‐Neutral Radical/Polar Crossover Reactions
Author(s) -
Wiles Rebecca J.,
Molander Gary A.
Publication year - 2020
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201900166
Subject(s) - photoredox catalysis , chemistry , reactivity (psychology) , ionic bonding , crossover , polar , photocatalysis , photochemistry , redox , catalysis , radical , combinatorial chemistry , organic chemistry , computer science , ion , physics , medicine , alternative medicine , pathology , astronomy , artificial intelligence
Radical/Polar Crossover (RPC) chemistry is a rapidly growing subset of photoredox catalysis that is characterized by transformations featuring both radical and ionic modes of reactivity. Net‐neutral RPC is particularly interesting in that both the single‐electron oxidation and reduction steps occur through interaction with the photocatalyst, thus precluding the need for exogenous oxidants or reductants. As such, these transformations facilitate rapid incorporation of molecular complexity while maintaining mild reaction conditions. This review covers recent advances in photoredox‐mediated net‐neutral RPC synthetic methods, with a particular emphasis on C–C bond‐forming reactions.