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Molecular Recognition of Water‐soluble Pillar[ n ]arenes Towards Biomolecules and Drugs
Author(s) -
Shu Xiaoyan,
Xu Kaidi,
Hou Dabin,
Li Chunju
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201800115
Subject(s) - pillar , chemistry , biomolecule , cationic polymerization , molecular recognition , binding affinities , affinities , molecule , water soluble , aqueous solution , combinatorial chemistry , aqueous medium , selectivity , nanotechnology , stereochemistry , organic chemistry , biochemistry , receptor , materials science , structural engineering , engineering , catalysis
The exploration of molecular recognition of synthetic macrocycles in aqueous media is significantly important since most biological functions, activities and processes take place in water. Pillar[ n ]arenes (n=5–10) have been recognized as a new generation of macrocyclic arenes; much attention has been devoted to their host‐guest chemistry. This review summarizes the host‐guest properties of water‐soluble pillararenes towards biologically significant molecules and drugs. These water‐soluble pillararenes are classified into three major classes according to the electric charges of hydrophilic groups at their portals: anionic pillar[ n ]arenes ( AP[ n ]s ), cationic pillar[ n ]arenes ( CP[ n ]s ), and neutral pillar[ n ]arenes ( NP[ n ]s ). The host–guest affinities, binding modes, binding selectivity, stimuli‐responsiveness, as well as biomedical applications are comprehensively discussed.