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Organic Mitoprobes based on Fluorogens with Aggregation‐Induced Emission
Author(s) -
Cai Xiaolei,
Hu Fang,
Feng Guangxue,
Kwok Ryan Tsz Kin,
Liu Bin,
Tang Ben Zhong
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201800031
Subject(s) - chemistry , aggregation induced emission , environmental chemistry , fluorescence , physics , quantum mechanics
Fluorescence imaging of mitochondria is of great interest to understand its functions and roles in various critical bioprocesses. Conventional fluorescence reagents for mitochondrial imaging and tracking suffer from various problems such as poor photostability and high cytotoxicity. The emerging of fluorogens with aggregation‐induced emission (AIE) property provides great opportunities to develop mitoprobes with high specificity, good photostability and multiple functions for mitochondrial imaging and tracking. This review summarizes the recent advance of AIE mitoprobes, including the design principle for AIE mitoprobes, the applications of AIE mitoprobes for super‐resolution mitochondrial imaging and tracking, as well as the therapeutic functions of AIE mitoprobes for cancer cell ablation.