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Alkane Carbon‐Hydrogen Bond Functionalization as a Tool Toward a Steric Parameter for Hydrotris(pyrazolyl)borate (Tp x ) Ligands
Author(s) -
Caballero Ana,
Pérez Pedro J.
Publication year - 2017
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700110
Subject(s) - chemistry , steric effects , regioselectivity , surface modification , olefin fiber , alkane , catalysis , boron , ethyl diazoacetate , cyclopropanation , hydrogen bond , medicinal chemistry , organic chemistry , molecule
The effect of a series of hydrotris(pyrazolyl)borate ligands (Tp x ) in the regioselectivity of the catalytic functionalization of the secondary carbon‐hydrogen bonds of hexane with ethyl diazoacetate and Tp x CuL as the catalysts has led to the definition of the relative steric parameter SP R . The validity of the parameter has been assessed upon its correlation with the regioselectivity observed in several transformations (olefin cyclopropanation, C−H functionalization, C−H amidation), in all cases a good degree of fitting being observed.