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Cucurbituril As A Versatile Tool to Tune the Functions of Proteins
Author(s) -
Hou Chunxi,
Zeng Xiangzhi,
Gao Yuzhou,
Qiao Shanpeng,
Zhang Xin,
Xu Jiayun,
Liu Junqiu
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700105
Subject(s) - cucurbituril , chemistry , supramolecular chemistry , combinatorial chemistry , nanotechnology , computational biology , molecule , organic chemistry , materials science , biology
Abstract Tuning the functions of proteins is a key issue in chemistry and biochemistry. The modification of proteins by chemical or biological methods is proven to be a classical method that allows proteins to achieve multiple functions. Compared with traditional methods, cucurbiturils as a new series of macrocyclic supramolecular hosts have been explored to modify and control protein functions because they could recognize and bind to short aromatic peptide sequences specifically. After guest molecules are incorporated into proteins by chemical and biological methods, CB[n]‐induced supramolecular protein assemblies show distinct functions in catalysis, biosensor and drug delivery. Herein we review the recent progress in the field of functional regulation of proteins with cucurbiturils.