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Hydrogen‐Mediated C−C Bond Formation: Stereo‐ and Site‐Selective Chemical Synthesis Beyond Stoichiometric Organometallic Reagents
Author(s) -
Schwartz Leyah A.,
Krische Michael J.
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700088
Subject(s) - chemistry , reagent , stoichiometry , redistribution (election) , organometallic chemistry , combinatorial chemistry , organic synthesis , hydrogen , group 2 organometallic chemistry , organic chemistry , catalysis , computational chemistry , molecule , politics , political science , law
Stereo‐ and site‐selective methods for the byproduct‐free modification of unprotected organic compounds that occur through the addition or redistribution of hydrogen are natural endpoints in the advancement of methods for efficient chemical synthesis. Progress toward this goal requires a departure from reactants that embody non‐native structural elements, including stoichiometric organometallic reagents, directing/protecting groups and chiral auxiliaries. In this perspective, we highlight how hydrogen‐mediated C−C bond formations developed in our laboratory have enabled progress toward ideal chemical syntheses of this type.