Inclusion Complexes of Hymexazol with Three Different Cucurbit[ n ]uril: Preparation, and Physicochemical and Antifungal Characterization | Zendy

Fan Ying | Zendy; Gao RuiHan | Zendy; Xiao Xin | Zendy; Tao Zhu | Zendy

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Inclusion Complexes of Hymexazol with Three Different Cucurbit[ n ]uril: Preparation, and Physicochemical and Antifungal Characterization

Author(s) -

Fan Ying,

Gao RuiHan,

Xiao Xin,

Tao Zhu

Publication year - 2018

Publication title -

israel journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.908

H-Index - 54

eISSN - 1869-5868

pISSN - 0021-2148

DOI - 10.1002/ijch.201700070

Subject(s) - chemistry , isothermal titration calorimetry , antifungal , mass spectrometry , titration , inclusion (mineral) , nuclear chemistry , proton nmr , crystallography , stereochemistry , chromatography , microbiology and biotechnology , mineralogy , biology

Host‐guest inclusion complexes of hymexazol with three different cucurbit[ n ]uril, cucurbit[7]uril (Q[7]), hemimethyl‐substituted cucurbit[6]uril (HHMeQ[6]), and twisted cucurbit[14]uril ( t Q[14]) have been investigated by means of 1 H NMR spectroscopy, quadrupole‐time of flight mass spectrometry (Q‐TOF), and isothermal titration calorimetry (ITC). 1 H NMR experimental results revealed that hymexazol resides within the respective cavities of the selected Q[ n ], and mass spectrometric experimental results revealed that it interacts with these three Q[ n ] through the formation of 1 : 1 inclusion complexes. ITC experimental results indicated moderate binding constants. In vitro assays showed that the complexation of hymexazol by the Q[ n ] increased its inhibitory effect on the mycelia growth of Botrytis cinerea Pers .

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