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Transition Metal‐Catalyzed Benzannulation towards Naturally Occurring Carbazole Alkaloids
Author(s) -
Zhang Xue,
Ma Shengming
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700034
Subject(s) - carbazole , chemistry , regioselectivity , catalysis , scope (computer science) , carbene , transition metal , combinatorial chemistry , atom economy , annulation , substrate (aquarium) , organic chemistry , oceanography , computer science , programming language , geology
In this account, we will summarize our recent progress on development of Pt‐ or Au‐catalyzed benzannulation of 1‐indolyl‐2,3‐allenols for the efficient construction of carbazole skeleton via a metal carbene intermediate and its application towards the synthesis of naturally occurring carbazole alkaloids. The strategy enjoys the outstanding regioselectivity, atom economy, mild reaction conditions, substrate scope, functional group tolerance.