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Gold(I)‐Catalyzed C−O/C−C Bond‐Forming Domino Reactions and Their Synthetic Applications
Author(s) -
Bihelovic Filip,
Vulovic Bojan,
Saicic Radomir N.
Publication year - 2018
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700033
Subject(s) - chemistry , domino , catalysis , combinatorial chemistry , organic chemistry
The advent of gold catalysis has transformed hydroxyalkoxylation of alkynes – once a rudimentary, mercury(II)‐, or silver(I)‐catalyzed process limited to structurally simple substrates – into a sophisticated method that has found application in syntheses of highly complex organic molecules. This transformation can further be combined with carbon‐carbon bond‐forming reactions into domino sequences that allow for a considerable increase of molecular complexity within a single synthetic step. Some recent examples of the development and synthetic applications of these reactions are provided.