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Recent Advances in Bifunctional Paramagnetic Chelates for MRI
Author(s) -
Giovenzana Giovanni B.,
Lattuada Luciano,
Negri Roberto
Publication year - 2017
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700028
Subject(s) - chemistry , bifunctional , chelation , moiety , biomolecule , paramagnetism , magnetic resonance imaging , gadolinium , molecular imaging , ligand (biochemistry) , nuclear magnetic resonance , denticity , mri contrast agent , in vivo , combinatorial chemistry , metal , stereochemistry , radiology , biochemistry , organic chemistry , medicine , physics , receptor , microbiology and biotechnology , quantum mechanics , biology , catalysis
Magnetic resonance imaging (MRI) is a non‐invasive diagnostic modality routinely employed in modern clinical medicine to collect images of the internal organs of the human body. Contrast agents (CA) are usually administered to patients to improve the sensitivity of this technique and nowadays these agents are gadolinium complexes. Bifunctional chelating agents (BFCAs) are dual molecules containing a multidentate ligand, able to strongly coordinate a metal ion, and a reactive moiety for conjugation purposes. With BFCAs an easy labelling of biomolecules or vectors with paramagnetic ions is possible, allowing the in vivo MRI visualization of diseases at cellular or molecular level.