Premium
Importance of DOTA derivatives in bimodal imaging
Author(s) -
Chilla Satya Narayana Murthy,
Henoumont Céline,
Elst Luce Vander,
Muller Robert N.,
Laurent Sophie
Publication year - 2017
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201700024
Subject(s) - dota , chemistry , gadolinium , magnetic resonance imaging , chelation , molecular imaging , positron emission tomography , biodistribution , europium , nuclear magnetic resonance , spect imaging , nuclear medicine , radiochemistry , radiology , in vivo , medicine , organic chemistry , physics , biochemistry , ion , microbiology and biotechnology , biology , in vitro
Abstract The clinical applications of multimodal probes are numerous since a few decades. 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) has played an important role in diagnostic and therapeutic areas. The vast applications of DOTA as chelator have been explored in magnetic resonance imaging (MRI) and in radioisotope chemistry. Moreover, the possibility to functionalize the macrocycle with pendant arms has allowed to explore new functionalities as bimodal imaging agents. Different combinations are possible between the different possible imaging techniques like Magnetic Resonance Imaging, Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Optical imaging (OI). The main use of DOTA and its derivatives was for MRI as gadolinium complexes. It was then further extended to the complexation with europium or terbium for optical imaging. Although other chelates are available such as DTPA or NOTA, derivatives of DOTA were often the primary choice due to their versatility. DOTA derivatives can indeed also be complexed with radioisotopes and conjugated to peptides which leads to targeted contrast agents for PET or SPECT. Depending on the chosen imaging modality, a variety of radiometals can be complexed with DOTA, e.i. 64 Cu and 68 Ga for PET, or 111 In and 90 Y for SPECT. Conjugation of chromophores to gadolinium complexes of DOTA derivatives can also lead to bimodal agents for MRI and OI. In this review, we will provide the applications of DOTA and its derivatives in different imaging modalities and their clinical applications.