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The Evolution and Impact of Total Synthesis on Chemistry, Biology and Medicine
Author(s) -
Nicolaou Kyriacos C.,
Rigol Stephan
Publication year - 2017
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201600087
Subject(s) - chemistry , set (abstract data type) , nanotechnology , engineering ethics , drug discovery , engineering , computer science , biochemistry , materials science , programming language
Abstract The advent of organic synthesis in the nineteenth century sparked a revolution in chemistry that led from a serendipitous discovery to the art and science that it is today. Its creative nature turned into enabling technologies that set in motion entire new industries such as the dye and pharmaceutical enterprises and helped elucidate and confirm structures of countless natural products. It also served as the locomotive for discovery and invention of new reactions, synthetic strategies and technologies, and delivered myriad valuable compounds, more or less complex, for research and applications in our everyday lives. Today it is a partner of biology in the quest of understanding living nature and applying the gathered intelligence to discover and develop newer and more effective drugs.