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Cerebrospinal Fluid Proteins as Regulators of Beta‐amyloid Aggregation and Toxicity
Author(s) -
Pate Kayla M.,
Murphy Regina M.
Publication year - 2017
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201600078
Subject(s) - chemistry , cerebrospinal fluid , amyloid (mycology) , amyloid beta , extracellular , amyloid β , beta (programming language) , disease , toxicity , alzheimer's disease , pathology , neuroscience , biochemistry , psychology , medicine , peptide , inorganic chemistry , organic chemistry , computer science , programming language
Amyloid disorders, such as Alzheimer's, are almost invariably late‐onset diseases. One defining diagnostic feature of Alzheimer's disease is the deposition of beta‐amyloid as extracellular plaques, primarily in the hippocampus. This raises the question: are there natural protective agents that prevent beta‐amyloid from depositing, and is it loss of this protection that leads to onset of disease? Proteins in cerebrospinal fluid (CSF) have been suggested to act as just such natural protective agents. Here, we describe some of the early evidence that led to this suggestion, and we discuss, in greater detail, two CSF proteins that have garnered the bulk of the attention.