Farnesol and  Candida albicans : Quorum Sensing or Not Quorum Sensing? | Zendy

Krom Bastiaan P. | Zendy; Levy Niva | Zendy; Meijler Michael M. | Zendy; JabraRizk Mary Ann | Zendy

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Farnesol and Candida albicans : Quorum Sensing or Not Quorum Sensing?

Author(s) -

Krom Bastiaan P.,

Levy Niva,

Meijler Michael M.,

JabraRizk Mary Ann

Publication year - 2016

Publication title -

israel journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.908

H-Index - 54

eISSN - 1869-5868

pISSN - 0021-2148

DOI - 10.1002/ijch.201500025

Subject(s) - farnesol , quorum sensing , candida albicans , chemistry , corpus albicans , microbiology and biotechnology , function (biology) , virulence , biochemistry , biology , gene

Quorum sensing (QS) molecules function within communities of single‐cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans .

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