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Farnesol and Candida albicans : Quorum Sensing or Not Quorum Sensing?
Author(s) -
Krom Bastiaan P.,
Levy Niva,
Meijler Michael M.,
JabraRizk Mary Ann
Publication year - 2016
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201500025
Subject(s) - farnesol , quorum sensing , candida albicans , chemistry , corpus albicans , microbiology and biotechnology , function (biology) , virulence , biochemistry , biology , gene
Quorum sensing (QS) molecules function within communities of single‐cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans .