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Towards Supramolecular Catalysis with Small Self‐assembled Peptides
Author(s) -
Singh Nishant,
TenaSolsona Marta,
Miravet Juan F.,
Escuder Beatriu
Publication year - 2015
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201400185
Subject(s) - chemistry , supramolecular chemistry , supramolecular catalysis , non covalent interactions , catalysis , combinatorial chemistry , self assembly , peptide , nanotechnology , amino acid , molecule , organic chemistry , biochemistry , hydrogen bond , materials science
Self‐assembly of small peptides offers unique opportunities for the bottom‐up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information‐rich, simple molecules based on amino acids can self‐organise autonomously into complex systems with emergent catalytic properties. The power of noncovalent interactions can be used to construct supramolecular peptidic tertiary structures. Moreover, specific functional groups present in amino acid side‐chains may present either a catalytic activity by themselves or be able to bind cofactors such as metal ions. In this scenario, although relevant progress has been achieved in recent years, promising applications in biomaterials science are foreseen. In this review, we discuss the state‐of‐the‐art of this approach at the interface between supramolecular chemistry and peptide science.