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A Triply Divergent Reagent for Glycoprotein Synthesis
Author(s) -
De Munari Sonia,
Schiffner Torben,
Davis Benjamin G.
Publication year - 2015
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201400182
Subject(s) - chemistry , reagent , glycan , glycoprotein , conjugate , combinatorial chemistry , linkage (software) , glycopeptide , flexibility (engineering) , biochemistry , stereochemistry , organic chemistry , gene , antibiotics , mathematical analysis , mathematics , statistics
Chemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one‐step diversification of a GlcNAc‐ylating reagent and its application in both site‐specific and non‐site‐specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds.