Chemistry Constraints on the Origin of Life

This analysis starts from the view that prebiotic chemical evolution, leading to the first forms of life on earth, was based on a series of sequential steps, each determined by its own contingent initial conditions. This view is opposed to the more established one, which sees the origin of life as a series of preordered series of events, where each one is deterministically caused by the previous one and causally determines the next one. Some of the main constraints of chemistry that affect such prebiotic chemical evolution are examined. The notion of contingency is seen as a very important organizing process subjected to chemistry, whereby contingency also responds to a certain degree of determinism. Kinetic control, as another determinant and constraint of the prebiotic evolutionary process, can be critically important and, at a certain point of the chemical evolutionary process, kinetic control in the form of catalysis will become essential. Simple peptides can be considered as the first catalysts, at least for the condensation of peptide bonds. The concentration threshold for prebiotic reactions is often not taken into account in the literature, particularly in the field of the prebiotic RNA world. In addition, this shortcoming can make the entire prebiotic RNA world construction shaky and unreliable, including the “myth” of the perennial self‐replication of an RNA macromolecule. The general question of self‐replication and the problem of homochirality are also briefly discussed. Although these chemical constraints may hinder the reconstruction of life as it is now in the laboratory, their understanding can be useful and even essential for devising a synthetic alternative route to functional macromolecules and to their metabolic interactions.