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Hybrid Nanoreactors: Coupling Enzymes and Small‐Molecule Catalysts within Virus‐Like Particles
Author(s) -
Patterson Dustin,
Edwards Ethan,
Douglas Trevor
Publication year - 2015
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201400092
Subject(s) - nanoreactor , catalysis , chemistry , artificial enzyme , nanotechnology , nanoparticle , combinatorial chemistry , scaffold , molecule , chemical engineering , organic chemistry , materials science , medicine , engineering , biomedical engineering
Virus‐like particles (VLPs) provide unique scaffolds for the construction of coupled catalytic systems by attachment and encapsulation of catalysts within their hollow interiors. The interior of VLPs provides an environment where catalysts of biological or synthetic origins can be confined, protected, and colocalized in close proximity with catalysts of different types. Herein, we utilize the P22VLP as a scaffold to construct a synthetic hybrid catalyst by attachment of a small organometallic catalyst to the interior colocalized with an encapsulated enzyme. This produces a complex and active coupled biomimetic catalyst system. By combining both enzymatic and synthetic catalysts together, new biologicalsynthetic hybrid materials can be produced that incorporate the best of both catalytic systems.