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Folding of Right‐ and Left‐Handed Three‐Helix Proteins
Author(s) -
Galzitskaya Oxana V.,
Pereyaslavets Leonid B.,
Glyakina Anna V.
Publication year - 2014
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201300146
Subject(s) - chemistry , folding (dsp implementation) , helix (gastropod) , protein folding , left handed , right handed , biophysics , helix turn helix , crystallography , biochemistry , dna binding protein , physics , gene , biology , ecology , optics , neutrino , snail , nuclear physics , transcription factor , electrical engineering , engineering
We are the first to investigate the relationship between protein handedness and the rate of protein folding. Our findings demonstrate that small three‐helix, left‐handed proteins are less densely packed and should result in faster folding than that of right‐handed, three‐helix proteins. At the same time, right‐handed, three‐helix proteins have higher mechanical stability than the left‐handed proteins. Moreover, from our analysis we have revealed that bacterial three‐helix proteins have some advantages in packing over eukaryotic right‐handed, three‐helix proteins, which should result in faster folding.