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Biomimetic Thiyl Radical Chemistry by γ‐Irradiation of Micelles and Vesicles Containing Unsaturated Fatty Acids
Author(s) -
Chatgilialoglu Chryssostomos,
Ferreri Carla,
Lykakis Ioannis N.,
Mihaljević Branka
Publication year - 2014
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201300091
Subject(s) - chemistry , isomerization , micelle , radical , vesicle , liposome , lipid vesicle , organic chemistry , biochemistry , catalysis , membrane , aqueous solution
Different types of lipid aggregations, such as micelles and liposomes, can be used as biomimetic models. The uses of γ‐irradiation as a valid methodology for simulating the biological generation of thiyl radicals in these models are summarized and, in particular, thiyl radical catalyzed cis trans isomerization of unsaturated lipids is underlined. The efficiency of antioxidants against lipid isomerization assayed by biomimetic models and the importance of trans lipids as novel biomarkers of radical stress are also described.