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Gold(I)‐Catalyzed Diastereoselective Domino Reactions of 2‐(1‐Alkynyl)alk‐2‐en‐1‐one Oxime Ethers with α,β‐Unsaturated Imines Consisting of 1,2‐Alkyl Migration
Author(s) -
Zhang Mei,
Zhang Junliang
Publication year - 2013
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201300070
Subject(s) - chemistry , oxime , alkyl , catalysis , domino , cycloaddition , medicinal chemistry , cascade reaction , stereochemistry , organic chemistry
A formal gold(I)‐catalyzed diastereoselective [4+3] cycloaddition of oxime ethers with imines, consisting of 1,2‐alkyl migration under mild reaction conditions, has been developed; this provides facile access to a series of highly substituted trans ‐pyrrolo[3,4‐ c ]azepines. This reaction is easily scaled up to the gram scale.