Premium
Nanopore‐Based Analysis of Chemically Modified DNA and Nucleic Acid Drug Targets
Author(s) -
Larkin Joseph,
Carson Spencer,
Stoloff Daniel H.,
Wanunu Meni
Publication year - 2013
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201300006
Subject(s) - nucleic acid , chemistry , nanopore , dna , nucleic acid quantitation , small molecule , nucleic acid structure , nanotechnology , epigenetics , computational biology , biochemistry , rna , gene , biology , materials science
Nucleic acids are central figures in many of life’s key molecular processes, e.g., enzymatic activity, epigenetics/gene regulation, viral replication, aging, cancer, and other diseases. Over the past two decades, nanopores have emerged as a new tool for studying the properties of nucleic acids at the single‐molecule level. In this review, we summarize the use of nanopores as sensors of nucleic acid structure, particularly for studying chemically modified and damaged DNA, and for probing the interactions of small‐molecule drugs with nucleic acid targets.