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Combined Enzyme and Transition‐Metal Catalysis for Dynamic Kinetic Resolutions
Author(s) -
Marcos Rocío,
MartínMatute Belén
Publication year - 2012
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201200012
Subject(s) - chemistry , kinetic resolution , transition metal , kinetic energy , catalysis , enzyme catalysis , amine gas treating , combinatorial chemistry , metal , axial symmetry , computational chemistry , organic chemistry , enantioselective synthesis , classical mechanics , physics , structural engineering , engineering
The preparation of optically pure alcohols, axially chiral allenes, and amine derivatives by using enzymes and transition‐metal catalysts through dynamic kinetic resolution (DKR) is reviewed. After a general introduction into enzymatic kinetic resolutions and racemizations catalyzed by transition‐metal complexes, selected examples of DKRs are presented, from early work to more recent outstanding contributions, and also applications of this approach.