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Synthesis of Nucleic Acid–Peptide Conjugates Targeted to Proteins
Author(s) -
Erben Anne,
Seitz Oliver
Publication year - 2011
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201100086
Subject(s) - nucleic acid , chemistry , peptide nucleic acid , peptide , conjugate , biochemistry , function (biology) , amino acid , nucleic acid methods , computational biology , combinatorial chemistry , microbiology and biotechnology , biology , mathematical analysis , mathematics
Nucleic acid–peptide conjugates have frequently been used to manipulate gene expression in living cells or to facilitate on‐array immobilization of peptides or proteins. Recently, it has been recognized that the programmed self‐assembly of nucleic acids can be used as a control element to confine the spatial arrangement or the conformation of peptides. This renders the hybrid molecules useful for studies of proteins and protein function, and could allow switching of the bioactivity of the appended peptides and thus the targeted protein by means of nucleic acid hybridization. A prerequisite of such studies is a feasible access to the desired chimeric molecules. This review describes recent efforts in the synthesis of nucleic acid–peptide hybrid molecules.