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Molecular Recognition of Amino Acids, Peptides, and Proteins by Cucurbit[ n ]uril Receptors
Author(s) -
Urbach Adam R.,
Ramalingam Vijayakumar
Publication year - 2011
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.201100035
Subject(s) - chemistry , supramolecular chemistry , affinities , receptor , binding affinities , cucurbituril , amino acid , molecular recognition , selectivity , aqueous medium , binding selectivity , combinatorial chemistry , aqueous solution , peptide , stereochemistry , biochemistry , molecule , organic chemistry , catalysis
At the forefront of the endeavor to understand and manipulate living systems is the design and study of receptors that bind with high affinity and selectivity to specific amino acids, peptides, and proteins. Cucurbit[ n ]urils are among the most promising class of synthetic receptors for these targets due to their high affinities and selectivities in aqueous media and to the unique combination of electrostatic and hydrophobic interactions that govern binding. The fundamental supramolecular chemistry in this area has been explored in depth, and novel, useful applications are beginning to emerge.