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Electrophilic Fluorination of Aromatics with Selectfluor™ and Trifluoromethanesulfonic Acid 1
Author(s) -
Shamma Tatyana,
Buchholz Herwig,
Prakash G.K. Surya,
Olah George A.
Publication year - 1999
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.199900026
Subject(s) - selectfluor , chemistry , electrophilic fluorination , octane , tetrafluoroborate , electrophile , reagent , organic chemistry , halogenation , medicinal chemistry , catalysis , ionic liquid
1‐(chloromethyl)‐4‐fluoro‐1,4‐diazabicyclo[2.2.2]octane bis (tetrafluoroborate) [Selectfluor™ F‐TEDA‐BF 4 (TEDA = triethylenediamine)] in the presence of trifluoromethanesulfonic acid has been found to be a very effective reagent system for the direct electrophilic fluorination of a wide variety of aromatic compounds under mild reaction conditions to the corresponding fluoroaromatics in good to excellent yields.

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