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Recent Developments in the Synthesis of Annonaceous Acetogenins
Author(s) -
Marshall James A.,
Hinkle Kevin W.,
Hagedorn Chad E.
Publication year - 1997
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.199700012
Subject(s) - chemistry , stereocenter , acetogenin , stereochemistry , organic chemistry , enantioselective synthesis , traditional medicine , annonaceae , catalysis , medicine
Synthetic routes to various bis‐THF annonaceous acetogenins and prototypes thereof are reviewed. These C 35 –C 37 long‐chain diethers exhibit a remarkable range of biological activities. The core unit, with six oxygenated stereogenic centers, provides a challenging target for asymmetric synthesis.