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Sequences and Structures of Retinal Proteins
Author(s) -
Tang Li,
Ebrey Thomas G.,
Subramaniam Shankar
Publication year - 1995
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.199500027
Subject(s) - rhodopsin , visual pigments , chemistry , retinal , function (biology) , projection (relational algebra) , visual field , pigment , computational biology , neuroscience , computer science , evolutionary biology , biochemistry , biology , algorithm , organic chemistry
The past few years have been an exciting period in the field of the structure of retinal proteins, especially the visual pigments. A significant achievement is the 9 Å projection map of bovine rhodopsin. This not only provides knowledge of the three‐dimensional structure of visual pigments, but also establishes a more reliable basis for the structural modeling of all the G‐protein‐coupled receptors. The modeling of such three‐dimensional structures will eventually lead to a better understanding of the function of visual pigments and other G‐protein‐coupled receptors. Our goal in this article is to draw attention to recent developments in the structure of retinal proteins, with special emphasis on visual pigments. By combining a wide range of existing experimental data with the results of theoretical calculations, a new three‐dimensional structure of visual pigments, which differs from the models which have so far been reported, is proposed.