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Solubilization of Proteins in Membranes
Author(s) -
Dan N.,
Safran S.A.
Publication year - 1995
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.199500008
Subject(s) - chemistry , membrane , adsorption , elasticity of cell membranes , solubilization , solubility , membrane protein , curvature , membrane biophysics , lipid bilayer , chemical engineering , biophysics , protein adsorption , biological membrane , membrane curvature , chromatography , biochemistry , organic chemistry , integral membrane protein , geometry , mathematics , engineering , biology
The solubility of proteins in membranes depends both on the protein properties and membrane characteristics. In this paper, we calculate the concentration of membrane inclusions as a function of their concentration in solution and the physical properties of the membrane. We find that the membrane deformation plays a key role in determining the adsorption. When there is no thickness mismatch between the inclusions and the membrane, the effective adsorption energy decreases with the lipid spontaneous curvature and hence strongly favors protein adsorption into the membrane.