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Field‐Flow Fractionation (FFF) and Related Techniques for the Separation of Particles, Colloids and Macromolecules
Author(s) -
Levin Shulamit
Publication year - 1990
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.199000026
Subject(s) - chemistry , field flow fractionation , fractionation , colloid , separation (statistics) , macromolecule , separation method , colloidal particle , field (mathematics) , chromatography , flow (mathematics) , chemical physics , nanotechnology , mechanics , physics , biochemistry , mathematics , pure mathematics , materials science , machine learning , computer science
Thin‐channel flow techniques can be used for the separation of samples ranging over 15 orders of magnitude in molecular weight, namely, macromolecules, colloids, and particles. The first part describes the group of field‐flow fractionation techniques. Flow system components are illustrated and described, as well as mode of operation and theory behind retention in the thin channel. An update of current topics under research is given, namely, normal retention mode of Brownian particles (under 1 μm in diameter) as compared to the steric retention mode of non‐Brownian particles (above 1 μm in diameter). Optimization of the separation by field programming is briefly discussed. Another group of thin‐channel techniques for small‐scale processing, the split‐flow thin (SPLITT) cells, in which fractionation is based on mass transport across the channel thickness, is presented in the second part. Principles of separation in this technology as well as possible applications are illustrated and discussed.