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Synthesis of Polymers Containing Lipoic Acid Structure and Study of the Acyl Transfer Reaction
Author(s) -
Okawara Makoto,
Fujimoto Atsuko,
Endo Takeshi
Publication year - 1978
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197800047
Subject(s) - chemistry , lipoic acid , amide , nucleophile , catalysis , amine gas treating , macromolecule , dithiolane , organic chemistry , polymer , alcohol , polymer chemistry , transfer hydrogenation , thiol , antioxidant , biochemistry , ruthenium
Several S‐acetyl and S,S‐diacetyl derivatives of dihydrolipoic acid and amide were prepared as model compounds to examine acyl transfer reactions similar to those in living systems. A macromolecule bearing the lipoic acid (1,2‐dithiolane) structure was synthesized by polymer reaction of polyacrylamide. The acyl transfer from these S‐acetates to nucleophiles such as amine, alcohol and thiol as well as the catalytic behavior of silver ion in these reactions was studied.