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Detection of Fragment Genesis in the Mass Spectrometer. IV. Peptide Sequencing by DADI‐MS
Author(s) -
Schlunegger Urs Peter,
Hirter Peter
Publication year - 1978
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197800027
Subject(s) - chemistry , tripeptide , oligopeptide , mass spectrometry , fragmentation (computing) , peptide , amino acid , sequence (biology) , monomer , stereochemistry , chromatography , biochemistry , organic chemistry , polymer , computer science , operating system
In oligomers, a structure element is repeated periodically. If a fragmentation pathway in the mass spectrometer is detectable arising from such a periodicity of structure, an analysis of the sequence of monomers is possible. This is the case in oligopeptides. Tracing the generation of consecutive ions stepwise by DADI‐MS leads successfully to the sequence of amino acids in tripeptides. This is demonstrated by different examples containing simple and more complex amino acids.