Premium
On the Polarographic Reduction of Griseofulvin and Some of its Derivatives
Author(s) -
Unterman H. W.,
Duca Al.
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400093
Subject(s) - chemistry , griseofulvin , polarography , reduction (mathematics) , biochemical engineering , combinatorial chemistry , inorganic chemistry , dermatology , medicine , geometry , mathematics , engineering
The mechanism of the polarographic reduction of griseofulvin was elucidated. The first wave is due to the 4′‐carbonyl group reduction, and the second to the C′ 2 ‐C′ 3 ethylenic linkage reduction. Substitution into the 2′‐ and 3′‐positions of griseofulvin or isogriseofulvin C ring, shifts appreciably the half‐wave potential values.