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Salicylates Attached to Polymers
Author(s) -
Weiner BenZion,
Havron Abraham,
Zilkha Albert
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400076
Subject(s) - chemistry , salicylic acid , polyvinyl alcohol , ether , organic chemistry , polymer , aspirin , alcohol , derivative (finance) , polymer chemistry , biochemistry , financial economics , economics
Several salicylate derivatives were attached to low molecular weight polyethylene oxides through an ether or carbonate linkage utilizing the respective halide or chlorocarbonate derivative of the polymers as reactive intermediates. Aspirin and 0‐salicoyl salicylic acid were attached to polyvinyl alcohol and cellulose acetate by ester linkage through melt esterification of the reactants. Preliminary pharmacological evaluation of some of the polymeric salicylates showed that they have a longer duration of antiinflammatory and analgesic activities as compared with aspirin.