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Preparation and Nucleophilic Reactions of β‐Fluoro‐γ‐Alkyl Halides
Author(s) -
Shahak Israel,
Ittah Ytzhak,
Bergmann E. D.
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400061
Subject(s) - chemistry , halide , alkyl , nucleophile , allylic rearrangement , nucleophilic addition , nucleophilic substitution , medicinal chemistry , fluorine , organic chemistry , catalysis
Problems related to the preparation of β‐fluoro‐γ‐alkyl halides and the nucleophilic reactions of these compounds are described. These compounds are found to be less reactive than the corresponding halides without the fluorine atom. Nucleophilic reactions of these halides are S N 2 reactions, and no allylic rearrangements are observed in any case.