The Ordered Polymer (Pro‐Gly‐Pro) n  an Immunological Model for Collagen | Zendy

Fuchs Sara | Zendy; Maoz Arieh | Zendy; Sela Michael | Zendy

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The Ordered Polymer (Pro‐Gly‐Pro) n an Immunological Model for Collagen

Author(s) -

Fuchs Sara,

Maoz Arieh,

Sela Michael

Publication year - 1974

Publication title -

israel journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.908

H-Index - 54

eISSN - 1869-5868

pISSN - 0021-2148

DOI - 10.1002/ijch.197400054

Subject(s) - immunogen , chemistry , polymer , gelatin , antigen , antibody , biophysics , biochemistry , immunology , monoclonal antibody , organic chemistry , biology

The periodic collagen‐like polytripeptide (Pro‐Gly‐Pro) n is immunogenic in several species of animals. Antibodies to this polymer are specific to the unique collagen‐like conformation of the immunogen. There is an immunological cross‐reactivity between (Pro‐Gly‐Pro) n and natural collagens in several systems, and it is possible to induce an autoimmune response to collagen by means of the synthetic polymer. The ordered polymer (Pro‐Gly‐Pro) n as well as collagen are thymus‐independent antigens, whereas the random polymer (Pro 66 , Gly 34 ) n and gelatin are thymus dependent.

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