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The Ordered Polymer (Pro‐Gly‐Pro) n an Immunological Model for Collagen
Author(s) -
Fuchs Sara,
Maoz Arieh,
Sela Michael
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400054
Subject(s) - immunogen , chemistry , polymer , gelatin , antigen , antibody , biophysics , biochemistry , immunology , monoclonal antibody , organic chemistry , biology
The periodic collagen‐like polytripeptide (Pro‐Gly‐Pro) n is immunogenic in several species of animals. Antibodies to this polymer are specific to the unique collagen‐like conformation of the immunogen. There is an immunological cross‐reactivity between (Pro‐Gly‐Pro) n and natural collagens in several systems, and it is possible to induce an autoimmune response to collagen by means of the synthetic polymer. The ordered polymer (Pro‐Gly‐Pro) n as well as collagen are thymus‐independent antigens, whereas the random polymer (Pro 66 , Gly 34 ) n and gelatin are thymus dependent.