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Conformational Behaviour of Non‐Ionizable Polypeptides in Gem‐Diol: Water Solvent Systems
Author(s) -
Lotan Noah,
Chen K.,
Roche R. S.
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400020
Subject(s) - chemistry , macromolecule , rigidity (electromagnetism) , polymer , solvent , circular dichroism , diol , similarity (geometry) , stereochemistry , polymer chemistry , organic chemistry , biochemistry , structural engineering , engineering , artificial intelligence , computer science , image (mathematics)
The conformation of poly‐N 5 ‐(2‐hydroxyethyl)‐L‐glutamine (PHEG) has been investigated in hexafluoropropan‐2,2‐diol‐water mixtures. In spite of the similarity of the circular dichroism spectra obtained in some of these mixtures and in water, NMR and hydrodynamic measurements revealed that macromolecular conformations of various degrees of rigidity are present in the different solvents considered. Homologue polymers of PHEG behave in a similar manner.