Premium
Cyclic Peptides VII . The Synthesis and Characterization of Cyclic Peptides with Repeating Pro‐Gly Sequences
Author(s) -
Deber Charles M.,
Blout Elkan R.
Publication year - 1974
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197400004
Subject(s) - chemistry , cyclic peptide , stereochemistry , thiocyanate , peptide , sequence (biology) , oligopeptide , sodium thiocyanate , biochemistry , organic chemistry
Abstract Four cyclic peptides of the type cyclo (Pro‐Gly) n were synthesized and characterized. The peptides are cyclo (L‐Pro‐Gly) 2 , cyclo (L‐Pro‐Gly) 3 , cyclo (L‐Pro‐Gly) 4 , and cyclo (D‐Pro‐Gly‐L‐Pro‐Gly). Aspects of the cyclization reactions leading to these peptides are discussed, particularly with respect to the choice of sequence of linear precursor peptides and effects of elevated temperatures. The cyclic octapeptide, cyclo (L‐Pro‐Gly) 4 , was isolated as a crystalline complex with sodium thiocyanate. Experimental details of the syntheses are provided.